Breast cancer collaborative reanalysis

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Comment in Lancet. Comment on Lancet. METHODS: Individual data from 47 epidemiological studies in 30 countries that included information on breastfeeding patterns and other aspects of childbearing were collected, checked, and analysed centrally, for women with invasive breast cancer and controls.

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SYNOPSIS: In a pooled analysis of prospective studies, researchers found an increased risk of breast cancer among parous women that persists for more than 20 years after childbirth. Breastfeeding did not modify this pattern. Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies.

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Data on 52, women with breast cancer andwomen without breast cancer from 51 studies in 21 countries were collected, checked and analysed centrally. Among current users of HRT or those who ceased use 1—4 years previously, the relative risk of having breast cancer diagnosed increased by a factor of 1. Five or more years after cessation of HRT use, there was no significant excess of breast cancer overall or in relation to duration of use.

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Hamajima, K. Hirose, K. Tajima, T.

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Background: Reproductive and hormonal factors are involved in the etiology of breast cancer, but there are only a few prospective studies on endogenous sex hormone levels and breast cancer risk. We reanalyzed the worldwide data from prospective studies to examine the relationship between the levels of endogenous sex hormones and breast cancer risk in postmenopausal women. Methods: We analyzed the individual data from nine prospective studies on women who developed breast cancer and women who did not.

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Published in British Journal of Cancer in Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Analyses included women with invasive breast cancer and controls from 53 studies.

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This report, on the relevance of breast cancer in first-degree relatives, is based on combined data from 52 epidemiological studies. METHODS: Individual data on breast cancer in first-degree relatives mothers, sisters, and daughters of women with breast cancer and of controls were collected, checked, and analysed centrally. Risk ratios for breast cancer were calculated by conditional logistic regression, stratified by study, age, menopausal status, number of sisters, parity, and age when the first child was born. Breast-cancer incidence and mortality rates for particular family histories were calculated by applying age-specific risk ratios to breast-cancer rates typical for more-developed countries.

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METHODS: Individual data from 47 epidemiological studies in 30 countries that included information on breastfeeding patterns and other aspects of childbearing were collected, checked, and analysed centrally, for women with invasive breast cancer and controls. Estimates of the relative risk for breast cancer associated with breastfeeding in parous women were obtained after stratification by fine divisions of age, parity, and women's ages when their first child was born, as well as by study and menopausal status. The relative risk of breast cancer decreased by 4.

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